Rebound effect

Rebound hypertension, above pre-treatment level, was observed after clonidine and guanfacine discontinuation. Continuous usage of topical decongestants (nasal sprays) can lead to constant nasal congestion, known as rhinitis medicamentosa. Many antidepressants, including SSRIs, can cause rebound depression, panic attacks, anxiety, and insomnia when discontinued. Many antihistamines, both first and second, can cause rebound pruritus, urticaria, allergic symptoms, and insomnia when discontinued. Examples of these medications include cetirizine, levocetirizine, and diphenhydramine. Sudden and severe emergence or re-emergence of psychosis may appear when antipsychotics are switched or discontinued too rapidly. Denosumab inhibits osteoclast recycling, which results in the accumulation of pre-osteoclasts and osteomorphs. When denosumab therapy is discontinued, the induced cells quite quickly and abundantly differentiate into osteoclasts causing bone resorption (rebound effect) and increasing the risk of fractures.